Sulindac placebo, 1 tablet, PO, daily for 3 years. Sulindac placebo one tablet PO daily for 3 years. Sulindac placebo 1 tablet PO daily for 3 years.
To evaluate whether intervention effects are 47440, an analysis of post-treatment follow-up, examining colorectal event rates through year 8 will be performed. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
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Talk with your doctor and family members or friends about deciding to a study. Sulindac placebo 1 tablet PO daily for 3 years. A time-to-event analysis will be conducted if there is no evidence of differential rates of on-study colonoscopies. Sulindac placebo one tablet PO daily for 3 years.
The genotype data, treatment characteristics and endpoints of interest will be analyzed using the pharmacogenetic-environment interaction approach described by Wacholder and colleagues. Sulindac placebo, 1 tablet, PO, daily for 3 years.
Experimental: Eflornithine plus sulindac Eflornithine two mg tablets PO daily for 3 years. The primary analysis of the 3-year event rate will be performed using logistic regression, testing the main effect of treatment and adjusting for the baseline stratification factor. Statistical assessments of association between the biomarker and the recurrence endpoints will be performed after converting the biomarker scores to ranks, which will facilitate detection of monotonic relationship s.
All patients who receive any treatment will be included in the analysis of adverse events.
For general information, Learn About Clinical Studies. A two-arm binomial de without continuity correction will be used.